The Toothy Spider (in-game name Kammolukki) is an enemy native to the Lukki Lair. It has large round jaws with many teeth. Unlike normal Lukki, it will attempt to attack with its mouth instead of its limbs. When inside its jaws you will take 60 melee damage per second.
As it heals from projectile and explosion damage, the most reliable ways to kill it are: Slice Spells, Freezing Gaze, Giga Black Hole or Tentacle (combined with Freeze Charge, a single tentacle is often enough to kill).