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Health Pickups are Pickups that can be collected in-game which generally have a beneficial effect, though their exact effect can vary. They all have a heart-shaped appearance, with some variance depending on the type of health pickup.

Full Health Regeneration[]

A Full Health Regeneration pickup.

Full Health Regeneration is a pickup which fully heals the player when picked up. When found in a Holy Mountain, it also increases the player's max HP by 10 ♥. It has a similar red and gold heart appearance to the Extra Max Health pickup, but lacks the plus sign in the upper right. Unlike Extra Max Health, this HP increase still takes effect after picking Glass Cannon, and its max HP increase is unaffected by the Extra Maximum HP from Hearts perk.

Full Health Regeneration containers can be found:

  • In Holy Mountains
  • Very rarely from treasure chests
  • In the Dark Cave

Extra Max Health[]

An Extra Max Health pickup.

Extra Max Health is a pickup which increases the player's maximum HP by 25 ♥, without healing them. It has the appearance of a large red heart with a golden border, as well as a plus sign in the upper right corner. If the player has picked the Stronger Hearts perk, maximum health will increase by 50 ♥ or more instead, depending on how many stacks of the perk the player has. If the player has picked Glass Cannon, this pickup has no effect and a message will be displayed stating that "some sort of curse" blocked the HP increase.

Extra Max Health containers can be found:

Large Extra Max Health[]

The Large Extra Max Health is a more potent version of the regular Extra Max Health, and increases the player's maximum HP by 50 ♥. They are much rarer than the normal Extra Max Health, and can only be found in Treasure Chests.

Cursed Extra Max Health[]

This content includes possible spoilers or secrets. Tread carefully.

An Orb of Corrupted Knowledge with its Cursed Extra Max Health pickup inside.

Cursed Extra Max Health is a pickup which can only be found in Parallel Worlds. It is found inside Orbs Of Corrupted Knowledge which take the place of all orbs in parallel worlds and appears as a sickly purple version of the other health pickups.

It shares the base effect of the Large Extra Max Health pickups, but also applies a hefty Poison effect to the player for 30 seconds, which will slowly chip away a large portion of the player's health. While this cannot kill the player normally, in New Game + the poison damage is heavily amplified and can kill the player on its own. By New Game ++++ (NG+4) the poison will deal more than the player's full health in damage per tick.

Ambrosia is highly recommended for collecting these pickups; waiting out the poison with a small amount of ambrosia negates the negative impact effectively.

Saving Grace is a must have perk to prevent the poison damage from one-shotting the player, while Glass Cannon will nullify the damage outright.

An Orb of Corrupted Knowledge with its Cursed Extra Max Health pickup inside.

Cursed Extra Max Health is a pickup which can only be found in Parallel Worlds. It is found inside Orbs Of Corrupted Knowledge which take the place of all orbs in parallel worlds and appears as a sickly purple version of the other health pickups.

It shares the base effect of the Large Extra Max Health pickups, but also applies a hefty Poison effect to the player for 30 seconds, which will slowly chip away a large portion of the player's health. While this cannot kill the player normally, in New Game + the poison damage is heavily amplified and can kill the player on its own. By New Game ++++ (NG+4) the poison will deal more than the player's full health in damage per tick.

Ambrosia is highly recommended for collecting these pickups; waiting out the poison with a small amount of ambrosia negates the negative impact effectively.

Saving Grace is a must have perk to prevent the poison damage from one-shotting the player, while Glass Cannon will nullify the damage outright.

An Orb of Corrupted Knowledge with its Cursed Extra Max Health pickup inside.

Cursed Extra Max Health is a pickup which can only be found in Parallel Worlds. It is found inside Orbs Of Corrupted Knowledge which take the place of all orbs in parallel worlds and appears as a sickly purple version of the other health pickups.

It shares the base effect of the Large Extra Max Health pickups, but also applies a hefty Poison effect to the player for 30 seconds, which will slowly chip away a large portion of the player's health. While this cannot kill the player normally, in New Game + the poison damage is heavily amplified and can kill the player on its own. By New Game ++++ (NG+4) the poison will deal more than the player's full health in damage per tick.

Ambrosia is highly recommended for collecting these pickups; waiting out the poison with a small amount of ambrosia negates the negative impact effectively.

Saving Grace is a must have perk to prevent the poison damage from one-shotting the player, while Glass Cannon will nullify the damage outright.

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