Orb of True Knowledge

Orbs of True Knowledge are collectibles that can be picked up by the player in the world. They are always accompanied by an Emerald Tablet, and many are also housed in Orb Rooms, which have hidden messages about the lore of the World when their basins are filled with specific contents.

Effects


When first collected, they will give the player a specific message depending on which Orb was collected and an accompanying spell, which also unlocks the spell for future runs. In all future runs, the player will instead receive a slightly different message (referring to the Orb as a Familiar Orb of True Knowledge) and an Extra Max Health pickup. Shortly after an orb is collected, an eerie sound will play with an accompanying ominous screen shake effect, hinting that something more is going on as well.

When at least one orb has been collected, a counter will appear below the wand mana or potion capacity bar indicating how many orbs have been collected. This counter does not appear until the player has at obtained at least 1 orb.

Kolmisilmä's health increases exponentially with each orb ; reaching if all 11 orbs in the main world have been collected.

Orbs of Corrupted Knowledge
Parallel Worlds have an alternate version known as Orbs of Corrupted Knowledge. They always drop Cursed Extra Max Health pickups instead of a spell or Extra Max Health.

Secret orb
It is possible, but extremely unlikely, to obtain a 34th orb from a Great Treasure Chest. The only guaranteed way to obtain this currently is via a set seed. This video by FuryForged explains the details: How to obtain 34 orbs for peak Noita drip - FuryForged